What is N-Benzyl-4-(benzylamino)picolinamide?

N-Benzyl-4-(benzylamino)picolinamide
Synonyma: N-BENZYL-4-(BENZYLAMINO)PICOLINAMIDE;4-(Benzylamino)-N-benzylpyridine-2-carboxamide;4-(Benzylamino)-N-benzylpyridine-2-carboxamide 98%
Molecular Formula:C20H19N3O
CAS No.: 913836-29-0
Molecular weight:317.38436
Picolinamide, 2-pyridinecarboxylic acid amide, was found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Another experiment using isolated pancreatic islets of rats showed that picolinamide protects against streptozotocin-induced depression of proinsulin synthesis as well as against streptozotocin-induced reduction of NAD content. The protection by picolinamide against the NAD depression was considered to be due to the blockage of an increased degradation of NAD mediated by a streptozotocin-induced increase in poly (ADP-ribose) synthetase activity.
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