Molecular Formula:C7H5F2NO3
CAS No.:66684-59-1
Molecular Formula: C7H5F2NO3
Molecular Weight:189.12
Melting point (oC): 96-99
o-Nitroanisole is reasonably anticipated to be a human carcinogen based on evidence of malignant tumor formation at multiple tissue sites in multiple species of experimental animals (For detasils See NTP, 1993).
When administered in the diet to male and female rats, o-nitroanisole induced increased incidences of mononuclear cell leukemia and neoplasms of the urinary bladder, kidney, and large intestine. When administered in the diet to male and female mice, o-nitroanisole induced increased incidences of benign and malignant hepatocellular neoplasms in males and increased incidences of hepatocellular adenomas in females.
PROPERTIES
O-nitroanisole is a colorless to slightly yellow liquid with a boiling point of 277°C and a melting point of 9-10°C. It is insoluble in water but is soluble in most organic solvents, including alcohol and ether. As a bulk chemical, o-nitroanisole is stable for two weeks at temperatures up to 60°C when stored protected from light. When heated to decomposition, o-nitroanisole emits toxic fumes of NOx.
USE
o-Nitroanisole is used primarily as a precursor to o-anisidine which is prepared by direct nitro-reduction. o-Anisidine is used extensively in the synthesis of azo dyes either directly after being converted to a diazonium salt or as a precursor for the preparation of dianisidine which is diazotized and coupled. Directly or indirectly, o-anisidine is used in the manufacture of over 100 azo dyes (For detasils See NTP, 1993). o-Nitroanisole has also been used as an intermediate for pharmaceuticals (IARC V.65, 1996).
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