CAS NO: 4570-45-0
Molecular Formula: C3H4N2O
Molecular Weight: 84.08
Melting Point:
Boiling Point: 186.679°C at 760 mmHg
Oxazole is the ancestor admixture for a all-inclusive chic of heterocyclic ambrosial amoebic compounds. These are azoles with an oxygen and a nitrogen afar by one carbon. Oxazoles are ambrosial compounds but beneath so than the thiazoles.
Oxazole is a anemic base; its conjugate acerbic has a pKa of 0.8, compared to 7 for imidazole.
Oxazolines can aswell be acquired from cycloisomerization of assertive propargyl amides. In one study oxazoles were able via a one-pot amalgam consisting of the abstract of propargyl amine and benzoyl chloride to the amide, followed by a Sonogashira coupling of the terminal alkyne end with addition agnate of benzoylchloride, and absolute with p-toluenesulfonic acerbic catalyzed cycloisomerization.
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