Vincristine can antitumor

Vincristine is apocynaceae plant vinca alkaloids extracted, because of anti-tumor effect is good, at present the preparations as clinical antitumor drugs. Keyword extraction and separation of structure and properties of pharmacological effects therapeutic method pharmacokinetic

Vincristine cancer and curative effect of about 10 times higher than that of vinblastine, can be used in the treatment of acute lymphocytic leukemia, curative effect is better, for other acute leukemia, Hodgkin's disease, lymphatic sarcoma, the reticular cell sarcoma and breast cancer also has curative effect. With VLB (vinblastine), los los together new and generic los wash dean in vinca alkaloids in flowers (Vincamajor). With the cell division (mitosis) stop in the medium term, this is similar to colchicine, but its effect was stronger than colchicine. Like colchicine can combine with tubulin and inhibit its biological activity, but the combination of different parts. It is different from colchicine outside of tubulin proteins such as actin and 10 nanometers filament protein also play a role. In clinical medicine, as one of the anticancer agent and has been applied, especially in hematopoietic organ lesions is effective. Vinblastine sulfate can be used in the treatment of Hodgkin's disease and chorionic carcinoma, curative effect is better; For lymphatic sarcoma, the reticular cell sarcoma, acute leukemia (VP, VDLP scheme of "V" for vincristine, D for soft erythromycin, "L" for winter amidase door, "P" for prednisone), breast cancer, renal tumor, ovarian and testicular cancer, neuroblastoma, and malignant melanoma also have certain curative effect.

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