Urokinase is by fresh urine separation, refining and a protein enzyme, usually white or white freeze-dried block or powder. Mainly made of enzymes to dissolve thrombus. It can activate fibrinolytic enzymes in the body into a fibrinolytic enzyme, thereby hydrolysis fibrin make new form of thrombolysis. It should be used immediately after dissolved and should not be stored.
pharmacological
1, the direct effects on endogenous fibrinolysis system, which can catalytic cracking fibrinolytic enzyme into a fibrinolytic enzyme.
Endogenous fibrinolysis system not only can degradation of fibrin clot, also can degrade fibrinogen in blood, and clotting factor Ⅴ and blood coagulation factor Ⅷ etc, which play a role of thrombolysis, the newly formed blood clots quick effect, the effect is good.
2 ADP enzyme activity, improve the blood vessels, inhibit the platelet aggregation induced by ADP, prevent thrombosis.
After intravenous drip, the patient's body fibrinolytic enzyme activity increased significantly; Stopped a few hours later, fibrinolytic enzyme activity to restore the original level, but the level of plasma fibrin and fibrinogen is reduced, and their degradation products increase sustainable 12-24 hours.
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