about Atazanavir sulphate

Applications; A sulphate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor
CAS Number: 229975-97-7
Purity: ≥98%
Molecular weight: 802.93
Formula: C38H52N6O7 • H2SO4
Solid state physics
Solubility: Soluble in water (4-5 mg / ml), and methanol.
Storage: Store at 4 ° C
Atazanavir sulphate is a sulphate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. Has shown to be generally more potent than the five currently approved HIV-1 Prt inhibitors. Atazanavir (BMS-232632) inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC50 of approximately 47 nM. Also highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23,000-fold higher than that required for anti-HIV activity. Atazanavir (BMS-232632) may be an effective HIV-1 inhibitor that may be utilized in a variety of different drug combinations.
from:Rare Metals