Learn what is its activity uses DDR1

Discoidin breadth receptor family, affiliate 1, aswell accustomed as DDR1 or CD167a (cluster of adverse 167a), is a beastly gene.

Receptor tyrosine kinases (RTKs) play a key role in the advice of beef with their microenvironment. These molecules are circuitous in the adjustment of corpuscle growth, adverse and metabolism. The protein encoded by this gene is a RTK that is broadly bidding in accustomed and adapted epithelial beef and is activated by assorted types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a affinity arena to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is accomplished by all collagens so far activated (type I to blazon VI). A carefully accompanying ancestors affiliate is the DDR2 protein. In situ studies and Northern-blot assay showed that announcement of this encoded protein is belted to epithelial cells, decidedly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is decidedly over-expressed in several beastly tumors from breast, ovarian, esophageal, and pediatric brain. This gene is amid on chromosome 6p21.3 in adjacency to several HLA chic I genes. Another splicing of this gene after-effects in assorted archetype variants.