Pharmacological action of protamine

Protamine is a affectionate of basal protein, mainly in angle ( such as salmon, trout, herring ) exists as a aggregate of DNA and complete abettor basis nuclear protamine. Protamine was apparent in 1870, to 1940 to 1960 years, was acclimated as the abstraction of antibacterial abettor was popular. Protamine in atomic agreement of collagen, and no axiological difference, are composed of amino acids. In the accomplished two years become a new adorableness products, are aswell fabricated for medical injection, because of bleeding acquired by bang of heparin overdose, and no added another medicines. Protamine showed antibacterial adeptness is actual able in aloof and acrid medium, and college thermal stability, heating at 210 ℃ for 1 SH is still active, and antibacterial ambit and aliment canning are wide, and its inhibition on Bacillus subtilis, bacillus, Lactobacillus casei, Lactobacillus plantarum, lactic acerbic bacteria, fungi, spores aggressive bacilli and gram-positive bacilli were strong, but adjoin Gram-negative bacilli inhibition aftereffect is not obvious. Acclimated as a preservative, because it is tasteless and odorless, controllable to the animal body, and accordingly use after any restrictions, according to the charge of bacteriostatic aftereffect can be added to a satisfactory, but the bulk of large, top cost, alone as a top value-added aliment or anatomic aliment preservatives.

Protamine is a affectionate of able base, can anatomy abiding salts with able acerbic sodium heparin or heparin and heparin anticoagulant aftereffect to lose. This artefact is rapid, intravenous administering aural 5 account and the aftereffect of heparin. But some heparin from circuitous break again. And 1 units of altered sources of heparin appropriate protamine is hardly different, 1mg this artefact can heparin sodium heparin sodium and 90 units from bovine lung alertness or 115 units from the abdominal film in preparation, heparin or 100 units from pig belly preparation. Protamine and heparin circuitous has not been elucidated in vivo metabolic about-face process. Protamine is a affectionate of anemic anticoagulants, can could cause boundless array time basis of brief extension. Protamine is a affectionate of basal protein arch allocation of angle abettor breaking out, accept assertive biological activity. In agreement of technology, can alone be extracted from angle sperm, not actinic synthesis, attached the yield. According to the State Aliment and Drug Administering database shows, China has approval three companies with protamine, which is a lot of Biologic Co Ltd, biologic accumulation Beijing Kaiyue Biologic Co. Ltd and acceptance to the biologic accumulation of the aboriginal Shanghai biochemical biologic bound company.

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